A single-dose live attenuated chimeric vaccine candidate against Zika virus

A Promising, Single-Dose, Live Attenuated Tetravalent Dengue Vaccine Candidate.

Dengue virus (DENV) represents a rapidly expanding global health threat, with approximately 40% of the world’s population now living in >100 countries at risk for DENV transmission, including the United States [1, 2]. In 2010, an estimated 390 million DENV infections occurred worldwide, of which 96 million were symptomatic [3]. DENV infections produce a spectrum of clinical disease. This includ...

Development of an Attenuated Live Virus Vaccine against Sheep Pox

λ-Red-Recombineering Live Attenuated ΔipaD Shigella dysenteriae from Iranian Isolates as A Candidate of Vaccine

Shigella species (spp.) are gram-negative bacteria that are responsible for shigellosis. Although it can be controlled via antibiotics, increasing number of antibiotic resistant isolates of Shigella have been reported. Therefore, other strategies such as production of specific vaccine against this organism could be a suitable therapeutic approach. Attenuated live vaccines produced by gene delet...

A review of prophylactic measure against brucellosis in human with a live attenuated vaccine

Identification of a Live Attenuated Vaccine Candidate for Tularemia Prophylaxis

Francisella tularensis is the causative agent of a fatal human disease, tularemia. F. tularensis was used in bioweapon programs in the past and is now classified as a category A select agent owing to its possible use in bioterror attacks. Despite over a century since its discovery, an effective vaccine is yet to be developed. In this study four transposon insertion mutants of F. tularensis live...